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AMOXICILLIN (TRIHYDRATE)
GENERAL
AMOXICILLIN is a semisynthetic antibiotic, an analog of ampicillin, with a broad spectrum of bactericidal activity against many gram-positive and gram-negative microorganisms. Chemically it is (2S,5R,6R)-6-[(R)-(-)-2-amino-2-(p-hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-
4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid trihydrate.
Amoxicillin is a member of the penicillin family of antibiotics. To extend the usefulness of the penicillins to the treatment of infections caused by gram-negative rods, the broad-spectrum penicillins (ampicillin, amoxicillin, carbenicillin, and ticarcillin) were developed. These penicillins are sensitive to penicillinase, but they are useful in treating urinary tract infections caused by gram-negative rods as well as in treating typhoid and enteric fevers. 
STRUCTURE  CAS NO.
AMOXICILLIN
26787-78-0
ACTIVITY
Antibacterial
MOL WT.
C16H19N3O5S-3H2O
419.5
SYNONYMS
6-{[Amino(4-hydroxy phenyl)acetyl]amino-3,3-dimethyl-7-oxo-4-thia-1-
azabicyclo [3,2,0]heptane-2-carboxylic acid trihydrate.
D-(-)-alpha-amino-p-hydroxybenzyl penicillin trihydrate. 
SPECIFICATION & DESCRIPTION
PROPERTY VALUE
Bibliography BP USP
Appearance  White or Almost White Powder
Identification  Comply Test 
Assay  98.0 - 100.5 % (on Anhydrous basis)
Clarity of Solution  Complies test 
Spec. Optical Rotation  +290° - +315° 
Heavy Metals  20 ppm max
N,N-Dimethylaniline  20 ppm max
Sulfated Ash  0.5% max
Water  11.50% - 14.50% 
pH  3.5 - 5.5 (0.25% W/V Solution)
Bulk Density 0.65 - 0.8 gr/ml (Compat Type)
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                                                       Mr. JEFFERY TSUI

 　 　
　 　 　 　
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