AMPICILLIN
(ANHYDROUS, TRIHYDRATE)
|
GENERAL |
AMPICILLIN
is a semisynthetic antibiotic, a member of the penicillin family
of antibiotics. To extend the usefulness of the penicillins
to the treatment of infections caused by gram-negative rods,
the broad-spectrum penicillins (ampicillin, amoxicillin, carbenicillin,
and ticarcillin) were developed. It is created by attaching
acid radicals to the central structure of 6-aminopenicillanic
acid. Chemically, it is D-(-)-6-(2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo |
[3.2.0]
heptane-2-carboxylic acid trihydrate. Similar in action
to penicillin G--the most widely used natural penicillin--ampicillin
(or alpha-aminobenzylpenicillin) is more stable in stomach acids
and therefore may be given orally; it is also more active against
certain strains of bacteria. It is used regularly to treat common
urinary-tract infections, some respiratory infections, and bacterial
meningitis in children, although many strains of Hemophilus
influenzae (the most common cause
of bacterial meningitis) are now resistant to ampicillin, and
it commonly is used along with other drugs.The potential side
effects of ampicillin are similar to those of other penicillins--i.e.,
chiefly allergic reactions ranging
from skin rashes and hives to life-threatening anaphylactic
shock (very rare). People who are allergic to other drugs in
this family are also likely to react to ampicillin. The incidence
of skin rashes is higher with ampicillin than with other penicillins,
a factor that suggests a possible toxic reaction
,
as well as a truly allergic response.
|
PRODUCT
IDENTIFICATION |
|
AMPICILLIN
ANHYDROUS |
AMPICILLIN
TRIHYDRATE |
CAS
No. |
69-53-4 |
7177-48-2 |
Formula |
C16H19N3O4S |
C16H19N3O4S-3H2O |
MOL
WT. |
349.4 |
403.5 |
ACTIVITY |
Antibacteria |
SYNONYMS |
Amcill;
Principen; (6R)-6-(a-Phenyl-D-Glycylamino) Penicillanic acid
Trihydrate D-(-)-6-(2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo |
[3.2.0]heptane-2-carboxylic
acid trihydrate; aminobenzylpenicillin trihydrate; alpha-aminobenzylpenicillin
trihydrate; amperil; ampichel; ampikel; ampinova; trafarbiot;
Amcap; amplin; acillin; princillin; Cymbi; divercillin; lifeampil;
morepen; pensyn; |
SPECIFICATION
& DESCRIPTION |
PROPERTY |
ANHYDROUS |
TRIHYDRATE |
Bibliography |
BP
/ USP |
Appearance |
White
or Almost White Crystalline Powder |
Identification |
Comply
Test |
Assay |
98.0
- 100.5 % |
98.0
min (on Anhydrous basis) |
Clarity
Of Solution |
Complies
test |
Spec.
Optical Rotation |
+280°
- +315° |
Heavy
Metals |
20
ppm max |
N,N-Dimethylaniline |
20
ppm max |
Sulfated
Ash |
0.5%
max |
Water |
- |
12.0%
- 14.50% |
pH |
3.5
- 5.5 (0.25% W/V Solution) |
Bulk
Density |
- |
0.7
- 0.8 gr/ml (Compat Type) |
COMMENTS |