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ADENINE

PRODUCT IDENTIFICATION
CAS NO. 73-24-5 (Base) ADENINE
2922-28-3 (HCl), 321-30-2 (Sulfate)
EINECS NO. 200-796-1
FORMULA C5H5N5
MOL WT. 135.13
H.S. CODE 2933.59
TOXICITY Oral rat LD50: 227 mg/kg
SYNONYMS Vitamin B4; 6-Aminopurine; 
1H-Purin-6-amine; Ade; Adenin; Adeninimine; 1,6-Dihydro-6-iminopurine; 3,6-Dihydro-6-iminopurine; 6-Amino-1H-purine; 6-Amino-3H-purine; 6-Amino-9H-purine; 6-Amino-7H-purine; 1,6-dihydro-6-imino-9H-Purine; 9H-Purin-6-yl-amin; 9H-Purine-6-amine; 
DERIVATION
CLASSIFICATION
PHYSICAL AND CHEMICAL PROPERTIES 
PHYSICAL STATE white to off-white crystalline powder
MELTING POINT  360 - 365 C
BOILING POINT
SPECIFIC GRAVITY 
SOLUBILITY IN WATER slightly soluble
pH
VAPOR DENSITY
AUTOIGNITION
NFPA RATINGS
REFRACTIVE INDEX
FLASH POINT
STABILITY Stable under ordinary conditions
GENERAL DESCRIPTION AND APPLICATIONS
Purine is a heterocyclic compound featured by a fused pyrimidine and imidazole rings composed of carbon and nitrogen atoms. The simplest one is purine itself and the two major purines are adenine(6-Aminopurine) and guanine(2-Amino-6-hydroxypurine). Other important purines are caffeine, uric acid, theobromine, and theophylline. Purine and its derivatives are biologically important components of nucleic acids (DNA, RNA) and coenzymes.
SALES SPECIFICATION
ADENINE BASE
APPEARANCE white to off-white crystalline powder
ASSAY 99.0% min
HEAVY METALS 10ppm max
RESIDUE ON IGNITION 0.1% max
LOSS ON DRYING 0.5% max
ADENINE HCl
APPEARANCE white to off-white crystalline powder
ASSAY 99.0% min
HEAVY METALS 10ppm max
RESIDUE ON IGNITION 0.1% max
LOSS ON DRYING 5.2% max
ADENINE SULFATE
APPEARANCE white to off-white crystalline powder
ASSAY 99.0% min
HEAVY METALS 10ppm max
RESIDUE ON IGNITION 0.1% max
LOSS ON DRYING 9.0% max
TRANSPORTATION
PACKING 20kgs in fiber drum
HAZARD CLASS Not regulated
UN NO.
OTHER INFORMATION
European Hazard Symbols: XI, Risk Phrases: 22, Safety Phrases: 22-26-36
GENERAL DESCRIPTION OF NUCLEOSIDE
Ribose is a pentose (five-carbon sugar) that is a component of the ribonucleic acid (RNA), where it alternates with phosphate groups to form the 'back-bone' of the RNA polymer and binds to nitrogenous bases. Ribose phosphates are components of the nucleotide coenzymes and are utilized by microorganisms in the synthesis of the amino acid histidine. Its close relative, deoxyribose, is a constituent of deoxyribonucleic acid (DNA), where it alternates with phosphate groups to form the 'back-bone' of the DNA polymer and binds to nitrogenous bases. The presence of deoxyribose instead of ribose is one difference between DNA and RNA. Ribose has one more oxygen atom in its molecule than deoxyribose. Ribose has a five member ring composed of four carbon atoms and one oxygen. Hydroxyl groups are attached to three of the carbons. The other carbon and a hydroxyl group are attached to one of the carbon atoms adjacent to the oxygen. In dexoyribose, the carbon furthest from the attached carbon is stripped of the oxygen atom in what would be a hydroxyl group in ribose. The sugar (ribose or deoxyribose) molecules in the nucleic acid are all oriented in the same direction. Their carbon atoms are numbered: the 5' carbon atom is always on the side of the sugar molecule that faces the leading end, while the 3' carbon atom always faces the tail end. Nucleotide is the structural unit of a nucleic acid. A nucleotide consists of either a nitrogenous heterocyclic base (purine or pyrimidine) , a pentose sugar (ribose or deoxyribose) and a phosphate group attached at the 5' position on the sugar. A nucleoside consists of only a pentose sugar linked to a purine or pyrimidine base, without a phosphate group. Purine bases are Adenine, Guanine and Hypoxanthine (examples of purine nucleosides are Adenosine, 2'-Deoxyadenosine, Guanosine, 2'-Deoxyguanosine, Inosine, 2'-Deoxyinosine). Pyrimidine bases are Cytosine, Thymine, and Uracil (examples of pyrimidine nucleosides are Cytidine, 2'-Deoxyguanosine, 5-Methyluridine, 2'-Deoxy-5-Methyluridine, Uridine, 2'-Deoxyuridine). The nucleoside derivatives are involved in important functions in cellular metabolism and are used to synthesize enzyme inhibitors, antiviral agents, and anticancer agents.
 
   
       
       
       
       
       
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