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ACETYLSALICYLIC
ACID
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| PRODUCT
IDENTIFICATION |
| CAS
NO. |
50-78-2 |
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| EINECS
NO. |
200-064-1 |
| FORMULA |
CH3COOC6H4COOH |
| MOL
WT. |
180.16 |
| H.S.
CODE |
3004.9 |
| TOXICITY |
Oral
rat LD50: 200 mg/kg |
| SYNONYMS |
ASPIRIN;
2-(acetyloxy)-Benzoic acid; Solpyron; Ecotrin; |
| Colfarit;
Asatylin; Acetophen; Acetosal; Rhodine; o-Acetoxybenzoic Acid;
Extren; Benaspir; Entericin; Bialpirinia; Contrheuma Retard;
Salicylic Acid Acetate; Acetylsalicylsaure (German); Acido Acetilsalicilico
(Italian); Acimetten; Acide Acetylsalicylique (French); Acido
o-Acetil-benzoico (Italian); 2-Acetoxybenzoova (Czech); Kyselina
Acetylsalicylova (Czech); |
| DERIVATION |
2-Hydroxy-Benzoic
Acid - Salicylic acid ( 69-72-7 ) |
| CLASSIFICATION |
|
| GENERAL
DESCRIPTION |
| Acetylsalicylic
Acid, also known by trade name Aspirin, is an acetyl derivative
of salicylic acid that is a white, crystalline, weakly acidic
substance, with melting point 137°C. It is useful in the relief
of headache and muscle and joint aches. Aspirin is also effective
in reducing fever, inflammation, and swelling and thus has been
used for treatment of rheumatoid arthritis, rheumatic fever,
and mild infection. Large doses cause acid-base imbalance and
respiratory disturbances and can be fatal, especially in children.
Acetaminophen (known by trade name Tylenol), which does not
cause gastric irritation but does lower fever and relieve pain,
is often substituted for Aspirin. |
| PHYSICAL
AND CHEMICAL PROPERTIES |
| PHYSICAL
STATE |
Odorless,
Colourless or a white crystalline powder |
| MELTING
POINT |
136
C (with decomposition) |
| BOLING
POINT |
140
C |
| SPECIFIC
GRAVITY |
1.35 |
| SOLUBILITY
IN WATER |
1g/100g
water @ 37C |
| pH |
|
| VAPOR
DENSITY |
|
| AUTOIGNITION |
|
| NFPA
RATINGS |
Health:
2 Flammability: 1 Reactivity: 0 |
| REFACTIVE
INDEX |
|
| FLASH
POINT |
|
| STABILITY |
Stable
in dry air (hydrolyzes in moist air, decomposes in hot water) |
| APPLICATIONS |
| It
is used in analgesics, anti-inflammatories, antipyretics, anticoagulants
and antirheumatics. It is also used as an additivr in food,
animal feed, drug and cosmetic. |
| SALES
SPECIFICATION |
| BIBLIOGRAPHY |
BP
/ USP / JP |
| APPEARANCE |
white
to off-white crystalline powder |
| IDENTITY |
Complies |
| SOLUTION
IN ETHANOL |
Colourless,
Clear |
| ASSAY |
99.5
to 100.5 % |
| FREE
SALICYLIC ACID |
0.1
% max |
| LOSS
ON DRYING |
0.5
% max |
| SULPHATED
ASH |
0.1
% max |
| HEAVY
METALS (as Pb) |
20
ppm max |
| RELATED
SUBSTANCES |
0.25%
max |
| PARTICLE
SIZE |
Retained
on 180 µm (50 % maximum) |
| Retained
on 710 µm (10 % maximum) |
| TRANSPORTATION |
| PACKING |
25kgs
in Fiber Drum |
| HAZARD
CLASS |
6.1
(Packing Group: III) |
| UN
NO. |
2811 |
| OTHER
INFORMATION |
| European
Hazard Symbols: XN, Risk Phrases: 22/36/37/38, Safety Phrases:26/28 |
| GENERAL
DESCRIPTION OF SALICYLIC ACID |
| Salicylic
Acid is a white crystalline powder or needle-shaped crystals
with sweetish taste; soluble in acetone, ether, alcohol, boiling
water, benzene and turpentine, sparingly soluble in chloroformbenzene,
slightly soluble in water; melts at 158 C. It is prepared commercially
by sodium salicylate which derived from sodium phenolate with
carbon dioxide under heating and pressure. It contains both
a hydroxyl and a carboxyl group, which react with either an
acid or an alcohol. The carboxyl group forms esters with alcohols;
e.g. methyl salicylate is formed with methanol, which used in
food flavorings and preservatives; menthyl salicylate is formed
with methanol, which is used in suntan lotions; phenyl salicylate
(called salol) is formed with phenol, which is used as an antiseptic
and antipyretic agent. The hydroxyl group reacts with acetic
acid to form acetylsalicylic acid (called aspirin). Salicylic
Acid is important for the preparation of other pharmaceutical
products, dyes, flavours, and preservatives. The sodium salt
(Sodium salicylate), a shiny white powder, is used for antiseptics
preparations and as a preservative. Salicylic Acid derivatives
are used in formulating flavors, preservatives and UV
absorbers for food and cosmetics as well as plastics. They are
used in manufacturing pharmaceuticals mainly analgestics and
antipyretics for the relief of pain and fever. |
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Certificate of Analysis
Product Name : Aspirin
Standard : B.P.1998 and USP25
|
| Item |
Specification |
Result |
| Characteristics |
Colorless crystals or White crystalline powder |
Conforms |
| Identification |
Positive |
Positive |
| Heavy metals |
≤10ppm |
Conforms |
| Melting point |
143oC |
143oC |
| Clarity |
Clear and colorless |
Conforms |
| Colour of solution |
≤GY4 |
Conforms |
| Acidity |
≤0.1ml |
≤0.1ml |
| Loss on drying |
≤0.5% |
0.06% |
| Related substances |
Up to standard |
Up to standard |
| Residue on ignition |
≤0.05% |
0.05% |
| Free salicylie acid |
≤0.05% |
0.015% |
| Chloride |
≤0.014% |
0.014% |
| Sulfate |
≤0.04% |
0.01% |
| Organic volatile impurities |
Up to standard |
Up to standard |
| Assay |
99.5-100.5% |
100.0% |
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This data is only for your information purposes and does not imply
guarantee for a certain application. |
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If you need
an indicative price to your country, please kindly advise the annual
quantity needed, destination port and we will send you our soonest
CNF(Cost + Freight) price. Your indication for a workable price
level will sure speed up our fastest service for you |
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We really need to get
feed back from our customers in order to improve our performances.
Any information about quotations from competitors will be welcomed
since we hope to work as a team with you.
Your kind help will be very much appreciated.
Best regards from SHENZHEN
, China
Mr. JEFFERY TSUI
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Material
Safety Data Sheet |
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If the above information
doesn't cover |
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