ARTEMETHER

Structure: C16H26O5

Chemical name:
[3R-(3R,5aS,6S,8aS,9R,10R,12S,12aR**)]-Decahydro-10-methoxy-3,6,9-trimethyl-

3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin; CAS Reg. N?71963-77-4

Molecular weight: 298.4

Chemical characteristics: The product presented here is the b-epimer of Artemether.

Lipophylic substance: practically insoluble in water; very soluble in dichloromethane R and acetone R; freely soluble in ethyl acetate R and dehydrated ethanol R.

Melting range: 84 - 86 癈

Pharmacalogical properties:

Remark: Artemether is synthetised from DHA using methanol and a catalyst in acidic medium. This results in the production of predominantly b阾a-artemether. The alpha-epimer is also present and causes a difficult purification of the product. The pure alpha product behaves differently and has a melting point of 100癈 whereas the b阾a-epimer has a melting point of 84-86癈.
Both the alpha and the b阾a-epimers are active antimalarials.
It is the purification and separation of alpha from b阾a that leads to low yields and hence this increases the costprice of Artemether significantly.　

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