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TRANEXAMIC ACID BP

  DMF IS AVAIBLE
  Tranexamic acid is a competitive inhibitor of plasminogen activation, and at much higher concentrations, a noncompetitive inhibitor of plasmin, i.e., actions similar to aminocaproic acid. Tranexamic acid is about 10 times more potent in vitro than aminocaproic acid.
Tranexamic acid binds more strongly than aminocaproic acid to both the strong and weak receptor sites of the plasminogen molecule in a ratio corresponding to the difference in potency between the compounds. Tranexamic acid in a concentration of 1 mg per mL does not aggregate platelets in vitro.
Tranexamic acid in concentrations up to 10 mg per mL blood has no influence on the platelet count, the coagulation time or various coagulation factors in whole blood or citrated blood from normal subjects. On the other hand, tranexamic acid in concentrations of 10 mg and 1 mg per mL blood prolongs the thrombin time.
The plasma protein binding of tranexamic acid is about 3% at therapeutic plasma levels and seems to be fully accounted for by its binding to plasminogen. Tranexamic acid does not bind to serum albumin.
Absorption of tranexamic acid after oral administration in humans represents approximately 30 to 50% of the ingested dose and bioavailability is not affected by food intake
   
        We deliver the product      to several customers in the chemical and technical industry.
Please note the Specification Data of       in the following table.
   
   

THE CERTIFICATE OF ANALYSIS

Material Name

Tranexamic acid

Specification:BP98

Batch No

0502004M

TotalQty:500kgs

Original Record

0003544

MNF date:06 FEB 2005

COA NO:

0502096

EXPIRY DATE:06 FEB 2009

Items

Manufacturer Standard BP98

Results

Characters

White ,Crystalling powder

Postive

Identification

A.IR spectrum is concordance with Tranexamic acid CRS

Postive

B.In TLC,the principal spot of test solution(b) is similar in postion,colour and size to that of reference solution(a)

Postive

C.After reaction with Benzoyl Chloride,melting point of the residue is 184 ℃ to 187 ℃

185℃

PH Value

0.05g/ml solution,6.5 to 8.0

7.56

Related Subtances Max

Any impurity each less than 1.0%(TLC)

0.50%

Cis-isomer(HPLC)

less than 0.5%

Complies

Bromides

less than 670ppm

Complies

Heavy Metals Max

20ppm

20ppm

Sulphated ash

0.10%

0.03%

Loss on drying Max

1.00%

0.38%

Assay(titration)

99.0%-101.0%

100.18%

 

Conclusion:

This batch complies with the specification of BP98

It is only pointed to the sample certificate of analysis.each batch have difference but meeting BP98

This certificate of analysis is issued according the Original Record 0003544.
   
  Applications    
       
  Packing &loading    
   25KGS NET /DRUMS,28 KGS/ G.W    
        This data is only for your information purposes and does not imply guarantee for a certain application.
      Please note: We do not deliver the product to private users!
   
       If you need an indicative price to your country, please kindly advise the annual quantity needed, destination port and we will send you our soonest CNF(Cost + Freight) price. Your indication for a workable price level will sure speed up our fastest service for you    
 

     We really need to get feed back from our customers in order to improve our performances.
Any information about quotations from competitors will be welcomed since we hope to work as a team with you.
Your kind help will be very much appreciated.

     Best regards from SHENZHEN , China

                                                       Mr. JEFFERY TSUI

   
       
  Material Safety Data Sheet    
       
  Related Information and Active Pharmaceutical Ingredients    
  Tranexamic acid (marketed in the UK under the trade name of "Cyclokapron") is
an antifibrinolytic agent which competitively ... The use of tranexamic acid has
superseded the use of amino caproic acid More OHC : Tranexamic acid
   
  Tranexamic Acid Drug Information    
  Tranexamic acid reduces red cell transfusion better than epsilon    
       
     
  If the above information doesn't cover
   

 Material Name

 Application

 Packing&loading

 MSDS

 

 

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