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5-9/Aa-Am/An-Az/B/Ca-Ce/Cf-Cz/Da-Dh/Di-Dz/E/F/G/H/I/J/K/L/M/N/O/Pa-Pf/
/Pj-Po/Pp-Pz/Q/R/Sa-Ss/St-y/Ta-Th/Ti-Tz/U/V/W/X/Y/Z
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offer you better
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Camptothecin
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| DESCRIPTION: |
| Camptothecin
is an alkaloid derived from the chinese tree Camptotheca
acuminata Decne. Camptothecin and its derivatives are unique
in their ability to inhibit DNA TopoisomeraseⅠ,
by stabilizing a covalent reaction intermediate termed the
cleavable complex which ultimately causes tumor cell death. In
clinical it is widely believed that camptothecin analogs
exhibited remarkable anti-tumour and anti-leukaemia activity.
Topoisomerase is a basilic enzyme in the process of DNA
replication, it is responsible for the winding/unwinding of
the supercoiled DNA composing the chromosomes. If the
chromosomes cannot be unwound, transcription of DNA message
cannot occur and the protein cannot be synthesized, it
ultimately causes cell death. Application of camptothecin in
clinic is limited due to serious side effects and poor
water-solubility. At present, some camptothecin analogs,either
semi-synthetic or synthetic drug based on camptothecin, have
been applied cancerous therapy such as topotecan and
irinotecan while others have been obtained satisfying curative
effects in clinic. |
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| Specifications:
98% |
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| Product
Information: |
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| CAS
Number: |
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7689-3-4 |
| Origin |
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Camptotheca
acuminata |
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| Molecular Formula: |
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C20H16N2O4 |
| Molecular
Weight: |
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348.36 |
| Appearance: |
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Yellow
Powder |
| Purity
by HPLC: |
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Minimum
98% |
| Solubility: |
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Clear
Yellow Solution at 50Mg/Ml in Dimethylsulfoxide or 1N
Sodiumhydroxide |
| Test
Item |
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Appearance,
Solubility, Loss on drying, Ash, Assay, Solvent Residual,
Pesticide Residual, Heavy Metals, Microbiological. |
| Packing: |
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Nt.W:500g/Al
drum, with the inner aluminum foil package |
| Storage: |
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The
product is stable stored at 2-8℃
and in a dampproof, airtight, lightresistat area for at least
two years. |
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Key Intermediates |
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Applications |
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Packing
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This data is only for your information purposes and does not imply
guarantee for a certain application. |
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If you need
an indicative price to your country, please kindly advise the annual
quantity needed, destination port and we will send you our soonest
CNF(Cost + Freight) price. Your indication for a workable price
level will sure speed up our fastest service for you |
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We really need to get
feed back from our customers in order to improve our performances.
Any information about quotations from competitors will be welcomed
since we hope to work as a team with you.
Your kind help will be very much appreciated.
Best regards from SHENZHEN
, China
Mr. JEFFERY TSUI
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Material
Safety Data Sheet |
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Related Information
and Materials |
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10-HydroxyCamptothecin |
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7-Ethyl-10-HydroxyCamptothecin
(SN38) |
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9-Amino-Camptothecin |
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9-Nitro-Camptothecin |
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Camptothecin |
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Irinotecan
Hydrochloride |
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Topotecan
Hydrochloride |
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If the above information
doesn't cover |
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