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¡¡Anti Malarial              

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¡¡ Malaria is the most common killer of all the parasitic diseases that affect human. About 2000 million live in endemic areas. 300million people are infected every year and most of them children. In sub-Saharan Africa, over a million children die annually from the disease (WHO 1998). Malaria is a complex multi-system disease affecting erythrocytes, the brain, lungs, kidneys, placenta and other tissues. Plasmodium, a unicellular eukaryotic cell of the protozoa group is the fatal parasite responsible for malaria. There are four species of this parasite, Plasmodium falciparum (malignant tertian), vivax (benign tertian malaria), malariae (quartan malaria) and ovale. (Ovale tertian). Plasmodium falciparum is the most important of the malaria plasmodium species. Epidemic of this age long disease has been attributed the difficulties in diagnosis and control. Although after long exposures, some people become protected with acquired immunity, there is never a complete sterile immunity acquired, even after so many exposures. It is reckoned that about 60 % of people infected show no symptoms, making case studies difficult. P. Falciparum malaria causes morbidity and deaths and is also influenced by other infectious diseases like measles and also malnutrition. Vector control has proven futile, so the main combat technique is through drug treatment, but this has so far not been a successful story because of the complexity of the protozoa ¡®s life cycle, both in man and in the mosquito vector. Immunisation would have been the next line of combat, but allelic diversity and antigenic variation makes it difficult to develop a suitable vaccine More...... ¡¡ ¡¡
¡¡ PHARMACOLOGY OF CURRENT MALARIA CHEMOTHERAPY ¡¡ ¡¡
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Artemether Ýï¼×ÃÑ
Artemisinin; Arteannuin ÇàÝïËØ
Amodiaquine hydrochloride USP24
Amodiaquine USP24
Artesunate ÇàÝïçúõ¥
Chloroquine Phosphate Á×ËáÂÈà­
Chloroquine sulphate Bp2000
Dihydroartemisinin Ë«ÇâÇàÝïËØ
Hydroxychlorquine sulphate  BP2000 USP24 ÁòËáôÇ»ùÂÈà­ 50-63-5
Malaridine Phosphate Á×Ëá¿©ÄÎà¤
Piperaquine Phosphate Á×Ëáßßà­
Primaquine Phosphate Á×Ëá²®°±à­
Pyrimethamine ÒÒ°·à×à¤
Quinine Dihydrochloride ¶þÑÎËá¿üÄþ
Quinine Sulfate ÁòËá¿üÄþ
Sulfadoxine »Ç°·¶àÐÁ
4,7-Dichloroquinoline
4-hydroxy-7-chloroquinoline
4-hydroxyl-7-chloro-N-oxygenquinoline
6-Hydroxy-3,4-dihydroquinolinone
   
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